简介：Theχcalculusisamodelofconcurrentandmobilesystems.Itemphasizesthatcommunicationsareinformationexchanges.Inthepaper,twoconstructionsareincorporatedintotheframeworkofthechicalculus,whichareasymmetriccommunicationandmismatchconditionwidelyusedinapplications.Sincethebarbedbisimilarityhasproveditsgeneralityandgaineditspopularityasaneffectiveapproachtogeneratingareasonableobservationalequivalence,westudyboththeoperationalandalgebraicpropertiesofthebarbedbisimilarityinthisenrichedcalculus.Theinvestigationsupportsanimprovedunderstandingofthebisimulationbehaviorsofthemodel.Italsogivesageneralpictureofhowthetwoconstructionsaffecttheobservationaltheory.

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简介：Unbalancedregionaldevelopmentcanbeexaminedbylookingatthemismatchbetweendemographicdistributionandeconomicdistributionacrosstheregions.UsingtheindicatorsmeasuringthedegreeofmismatchbetweendemographicandeconomicdistributionoftheregionsinChina,thispaperrevisitsthedisparitiesandtheirchangesinregionaldevelopment,indentifyingaconvergingtrendintheregionaldifferencesafter2003.Bydecomposingtheregionaldifferencesintocontributionsofdemographicandeconomicconcentrations,thispaperalsoexploresthemechanismsofchangingregionaldifferences,andconcludesthatthechangesofregionaldifferencesaremoreattributabletotheeffectsofeconomicgatheringthantothoseofdemographicgathering.Demographicconcentrationisplayinganincreasinglyimportantroleinreducingtheregionaldifferenceswithreducingbarrierstopopulationmobility.ThepaperalsodiscussespolicyapproachesaddressingbalancedregionaldevelopmentinChina.

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简介：Wepresentarecentnumericalanalysisofimpedancemismatchtechniqueappliedtocarbonequationofstatemeasurements.Weconsiderhigh-powerlaserpulseswithaGaussiantemporalprofileofdifferentdurations.Weshowthatforthelaserintensity(≈1014W/cm2)andthetargetdesignconsideredinthispaperweneedtohavelaserpulseswithrise-timelessthan150ps.

简介：Awayofresolvingspreadingcodemismatchesinblindmultiuserdetectionwithaparticleswarmoptimization(PSO)approachisproposed.IthasbeenshownthatthePSOalgorithmincorporatingthelinearsystemofthedecorrelatingdetector,whichistermedasdecorrelatingPSO(DPSO),cansignificantlyimprovethebiterrorrate(BER)andthesystemcapacity.Asthecodemismatchoccurs,theoutputBERperformanceisvulnerabletodegradationforDPSO.Withablinddecorrelatingscheme,theproposedblindDPSO(BDPSO)offersmorerobustcapabilitiesoverexistingDPSOundercodemismatchscenarios.

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简介：Thestudyofsmalldrugmoleculesinteractingwithnucleicacidsisanareaofintenseresearchthathasparticularrelevanceinourunderstandingofrelativemechanisminchemotherapeuticapplicationsandtheassociationbetweengenetics(includingsequencevariation)anddrugresponse.Inthiscontribution,wedemonstratehowthesequence-specificbindingofananticancerdrugDacarbazine(DTIC)tosinglebase(A-G)mismatchcouldbesensitivelydetectedbycombiningelectrochemicaldetectionwithbiosensingsurfacebasedongoldnanoparticles.

简介：AIM:Toanalyzethemismatchrepair(MMR)statusandtheARID1Aexpressionaswellastheirclinicopathologicalsignificanceingastricadenocarcinomas.METHODS:WeexaminedtheexpressionsofMMRproteinsandARID1Abyimmunohistochemistryinconsecutive489primarygastricadenocarcinomas.Theresultswerefurthercorrelatedwithclinicopathologicalvariables.RESULTS:ThelossofanyMMRproteinexpression,indicativeofMMRdeficiency,wasobservedin38cases(7.8%)andwassignificantlyassociatedwithanolderage(68.6±9.2vs60.4±11.7,P<0.001),afemalesex(55.3%vs31.3%,P=0.004),anantrallocation(44.7%vs25.7%,P=0.021),andadifferentiatedhistology(57.9%vs39.7%,P=0.023).AbnormalARID1Aexpression,includingreducedorlossofARID1Aexpression,wasobservedin109cases(22.3%)andwassignificantlycorrelatedwithlymphaticinvasion(80.7%vs69.5%,P=0.022)andlymphnodemetastasis(83.5%vs73.7%,P=0.042).ThetumorswithabnormalARID1AexpressionmorefrequentlyindicatedMMRdeficiency(47.4%vs20.2%,P<0.001).AmultivariateanalysisidentifiedabnormalARID1Aexpressionasanindependentpoorprognosticfactor(HR=1.36,95%CI:1.01-1.84;P=0.040).CONCLUSION:OurobservationssuggestthattheAIRD1Ainactivationisassociatedwithlymphaticinvasion,lymphnodemetastasis,poorprognosis,andMMRdeficiencyingastricadenocarcinomas.

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简介：目的：开发一个新奇方法由DHPLC检测CpGmethylation。方法：在DNA与钠重亚硫酸盐被对待以后，失配修理基因hMLHl倡导者被聚合酶链反应(PCR)放大。DHPLC被用来在他们的部分使中毒的温度分开PCR产品。BstUI消化试金也为比较学习被使用。结果：A294bp乐队被PCR在结肠癌房间线RKO和胃的癌症房间线PACM82的每件DNA样品以后获得。这二个乐队能被DHPLC在53掳C(为RKO的保留时间6.7min对为PACM82的6.2min)完全分开。当PACM82不是methylated时，自从methylation能保护C的变换到T并且在重亚硫酸盐治疗以后使更高的C/G满意，我们断定在RKO房间的hMLHl倡导者是methylated，导致推迟的时间。从BstUI消化试金的与那些一致的这些结果。结论：在hMLHl的CpG岛的Methylation能被DHPLC在重亚硫酸盐修正以后方便地检测。

简介：AbstractBackground:The complement system plays an important role in the immune response to transplantation, and the diagnostic significance of peritubular capillary (PTC) C4d deposition (C4d+) in grafts is controversial. The study aimed to fully investigate the risk factors for PTC C4d+ and analyze its significance in biopsy pathology of kidney transplantation.Methods:This retrospective study included 124 cases of kidney transplant with graft biopsy and donor-specific antibody (DSA) testing from January 2017 to December 2019 in a single center. The effects of recipient pathological indicators, eplet mismatch (MM), and DSAs on PTC C4d+ were examined using univariate and multivariate logistic regression analyses.Results:In total, 35/124 (28%) were PTC C4d+, including 21 with antibody-mediated rejection (AMR), eight with renal tubular injury, three with T cell-mediated rejection, one with glomerular disease, and two others. Univariate analysis revealed that DSAs (P < 0.001), glomerulitis (P < 0.001), peritubular capillaritis (P < 0.001), and human leukocyte antigen (HLA) B eplet MM (P = 0.010) were the influencing factors of PTC C4d+. According to multivariate analysis, DSAs (odds ratio [OR]: 9.608, 95% confidence interval [CI]: 2.742-33.668, P < 0.001), glomerulitis (OR: 3.581, 95%CI: 1.246-10.289, P = 0.018), and HLA B eplet MM (OR: 1.166, 95%CI: 1.005-1.353, P= 0.042) were the independent risk factors for PTC C4d+. In receiver operating characteristic curve analysis, the area under the curve was increased to 0.831 for predicting PTC C4d+ when considering glomerulitis, DSAs, and HLA B eplet MM. The proportions of HLA I DSAs and PTC C4d+ in active antibody-mediated rejection were 12/17 and 15/17, respectively; the proportions of HLA class II DSAs and PTC C4d+ in chronic AMR were 8/12 and 7/12, respectively. Furthermore, the higher the PTC C4d+ score was, the more serious the urinary occult blood and proteinuria of recipients at the time of biopsy.Conclusions:PTC C4d+ was mainly observed in AMR cases. DSAs, glomerulitis, and HLA B eplet MM are the independent risk factors for PTC C4d+.