简介：Theoptimallyweightedleastsquaresestimateandthelinearminimumvarianceestimatearetwoofthemostpopularestimationmethodsforalinearmodel.Inthispaper,theauthorsmakeacomprehensivediscussionabouttherelationshipbetweenthetwoestimates.Firstly,theauthorsconsidertheclassicallinearmodelinwhichthecoefficientmatrixofthelinearmodelisdeterministic,andthenecessaryandsufficientconditionforequivalenceofthetwoestimatesisderived.Moreover,undercertainconditionsonvariancematrixinvertibility,thetwoestimatescanbeidenticalprovidedthattheyusethesameaprioriinformationoftheparameterbeingestimated.Secondly,theauthorsconsiderthelinearmodelwithrandomcoefficientmatrixwhichiscalledtheextendedlinearmodel;undercertainconditionsonvariancematrixinvertibility,itisprovedthattheformeroutperformsthelatterwhenusingthesameaprioriinformationoftheparameter.

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简介：AbstractBackground:The transmission and fatal risk of severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease first discovered in China in 2009, still needed further quantification. This research aimed to analyze the SFTS clusters and assess the transmission and mortality risk for SFTS.Methods:Both epidemiological investigation and case reports regarding SFTS clusters in China during 2011-2021 were obtained from the Public Health Emergency Information Management System of the Chinese Center for Disease Control and Prevention Information System. The transmission risk was evaluated by using the secondary attack rate (SAR) and relative risk (RR). Mortality risk factors were analyzed using a logistic regression model.Results:There were 35 SFTS clusters during 2011-2021 involving 118 patients with a fatality rate of 22.0%. The number of clusters annually increased seasonally from April to September. The clusters mainly occurred in Anhui (16 clusters) and Shandong provinces (8 clusters). The SAR through contact with blood or bloody fluids was much higher than that through contact with non-bloody fluids (50.6% vs 3.0%; χ2 = 210.97, P < 0.05), with an RR of 16.61 [95% confidence interval (CI): 10.23-26.97]. There was a statistically significant difference in the SAR between exposure to the blood of a deceased person during burial preparation and exposure to the living patients’ blood (66.7% vs 34.5%; χ2= 6.40, P < 0.05), with an RR of 1.93 (95% CI: 1.11-3.37). The mortality risk factors were a long interval from onset to diagnosis [odds ratio (OR)= 1.385), 95% CI: 1.083-1.772, P= 0.009) and advanced age (OR: 1.095, 95% CI: 1.031-1.163, P= 0.01).Conclusions:The SFTS clusters showed a high mortality rate and resulted in a high SAR. Contact with a bleeding corpse was associated with a higher infection risk, compared with contacting the blood from living patients. It is important to promote early detection and appropriate case management of patients with SFTS, as well as improved handling of their corpses, to prevent further transmission and mortality.

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简介：在这份报纸，作者证明吉本斯的类似物推测为象在一个给定的方向在无穷收敛到一样的价值的一些答案的Liouville类型结果一样在N,扩大了第四个顺序Allen-Cahn方程。作者也证明priori跳并且为semilinear推进一个维的对称和刚硬结果第四份订单有更一般的非线性的椭圆形的方程。

简介：瞄准：用液体血管注射剂硅酮与阴茎尺寸扩大报导我们的经验。方法：在2003年8月和2006年7月之间，324个人(意味着年龄35年，range19-65年)在阴茎柄的背面、侧面的方面上收到了在阴茎皮肤和阴茎海绵体之间的一系列液体硅酮皮下注射，在局部麻醉下面。数字相片拿的过程前并且过程以后(n=324)，并且阴茎轮廓大小(n=30)产出的客观结果。主观结果从病人和满足的搭挡证词被导出。后续平均20个月(范围1-36月)。结果：Threehundred和24个过程是主要扩大。大多数人(61%)结婚了，7%被他们的搭挡伴随，并且93%被割除。吝啬的测量阴茎圆周was9.5厘米(7.5-11.5厘米)预告的处理和12.1厘米(10.3-15.3厘米)处理以后(在直径的圆周和0.84厘米的27%的吝啬的增加)。病人和搭挡满足已经在开始的二治疗以后被表示。性欲活动能在8h以后被恢复。复杂并发症(温和檫伤)容易被解决。结论：阴茎尺寸扩大使用液体血管注射剂硅酮没有立即或短期的复杂并发症产出很令人满意的短期的结果。

简介：Inthispaper,wediscusstheexistenceanduniquenessofmildsolutionsofrandomimpulsiveabstractneutralpartialdifferentialequationsinarealseparableHilbertspace.TheresultsareobtainedbyusingLeray-SchauderAlternativeandBanachContractionPrinciple.Finallyanexampleisgiventoillustrateourproblem.

简介：AbstractPurpose:Tibial plateau fracture (TPF) is a devastating injury as it shatters lower articular surface of the largest joint. Apart from bony injury, TPF can lead to great soft tissue envelope compromise which affects the treatment plan and outcome. In the present study, clinical results were assessed in cases of high energy TPFs treated in staged manner.Methods:Twenty-three (20 males and 3 females) patients of high energy communited TPFs (Schatzker type V and VI) were consecutively treated.1 All the patient had compromise of overlying skin conditions. They were all successively scheduled for staged treatment plan which comprised of application of bridging knee external fixator on the first day of admission and definitive internal fixation after skin and soft tissue overlying the fracture were healed. Schatzker type I, II, III and IV were excluded from the study. Primary survey was done and patient who had head injury, chest and abdominal injury, pelvic injury and contralateral limb injury and open fractures were excluded from the study. The patients were also evaluated in terms of wound complications, axial and rotary alignment of limb, fixation failure, articular congruity and range of motion of the knees and post injury employment. Statistical analysis was done using SPSS software.Results:Maximum follow-up period was 13 months. All the fractures were united at final follow-up. Clinical evaluation was done with the Tegner Lysholm knee scoring scale.2 Excellent results were found in 78% cases and good and fair results in 22% cases. There was significant correlation between range of motion and the Tegner Lysholm knee score (p < 0.001, Pearson correlation coefficient = 0.741). The correlation between the score and the radiographical union duration was significant (p = 0.006, Pearson correlation coefficient =-0.554).Conclusion:A staged treatment plan allows healing of soft tissue envelope, with avoidance of dreadful complications such as compartment syndrome and chronic infection. In addition, a staged treatment strategy does not hamper the fracture reduction, bony union and the functional results.

简介：AbstractImportance:Several studies conducted worldwide (mostly in Western countries) highlighted the negative effects of problematic internet use, particularly among adolescents aged 12 to 17, including depression, impulsivity, aggression, and social fear and avoidance. In Lebanon, literature on the prevalence and impact of problematic internet use among adolescents is limited.Objective:This study aim was to study the association between problematic internet use and depression, impulsivity, anger, aggression and social phobia among Lebanese adolescents.Methods:A cross-sectional study was performed on 1103 young adolescents (14-17 years), recruited from October 2017 till April 2018. The Internet Addiction Test (IAT) was used to evaluate the level of problematic internet use. Data were analyzed using the MANCOVA analysis. The main independent variable of interest was the IAT, while the dependent variables included the psychological scales.Results:The multivariate analysis taking the psychological scales as the dependent variables and the problematic internet use (IAT score) as an independent variable, showed that problematic internet use was associated with higher depression, impulsivity, aggression, anger, hostility and social anxiety.Interpretation:Problematic internet use has become an important health issue that should not be overlooked, particularly because of the increased use of the internet by adolescents. Educational programs on early exposure to the internet should be developed.

简介：AbstractBackground:The association between sex hormone-binding globulin (SHBG) and renal function has rarely been reported in men. We aimed to investigate the above association in a community-based Chinese population.Methods:A total of 5027 men were included from the survey on prevalence for metabolic diseases and risk factors, which is a population-based study conducted from 2014 to 2016 in Eastern China. The estimated glomerular filtration rate (eGFR) was calculated according to the chronic kidney disease Epidemiology Collaboration equation. Low eGFR was defined as eGFR <60 mL·min-1·1.73 m-2.Results:After adjusting for age, smoking, metabolic factors, and testosterone, through increasing quartiles of SHBG, a significantly positive association between SHBG quartiles and eGFR was detected in men (Q1 vs. Q4, β -2.53, 95% confidence interval -3.89,-1.17, Ptrend < 0.001). Compared with the highest quartile of SHBG, SHBG in the lowest quartile was associated with 96% higher odds of low eGFR (odds ratio 1.96, 95% confidence interval 1.10, 3.48) in the model after full adjustment. According to the stratified analyses, the associations between a 1-standard deviation increase in serum SHBG and the prevalence of low eGFR were significant in men aged ≥60 years old, waist circumference <90 cm, diabetes (no), hypertension (yes), dyslipidemia (no), and nonalcoholic fatty liver disease (no).Conclusions:Lower serum SHBG levels were significantly associated with lower eGFR and a higher prevalence of low eGFR in Chinese men independent of demographics, lifestyle, metabolic-related risk factors, and testosterone. Large prospective cohort and basic mechanistic studies are warranted in the future.

简介：Theenergybarriersofthermaldecarboxylationreactionsofpetroleumacidsandcatalyticdecar-boxylationreactionsofBrnstedacidandLewisacidwereanalyzedusingmolecularsimulationtechnology.Comparedwiththermaldecarboxylationreactionsofpetroleumacids,thedecarboxylationreactionsbyacidcatalystswereeasiertooccur.ThedecarboxylatoneffectbyLewisacidwasbetterthanBrnstedacid.Themechanismsofcatalyticdecarboxylationoveracidcatalystwerealsoverifiedbyexperimentsonafixedbedandafluidizedbed,theexperimentalresultsshowedthattherateofacidremovalcouldreachupto97%overtheacidiccatalystatatemperatureabove400.

简介：用地震断层摄影术的最近的结果，我们学习了深构造的背景中等并且在安徽省和它的附近的区域的强震(28°～39°N，112°～124°E)。结果如下：(1)在那里存在在中等强壮的地震，表面的地质的结构并且与上面外壳的速度划分活跃构造元素的地点之间的某个关联组织。记录M≥的大多数地震6.0发生在高速度的地区或在在high-velocityand之间的过渡区域在上地壳的低速度的地区。在低速度的地区的地震活动有更小的影响。发生在高速度的地区的地震主要在速度变化区域被散布。边界带和北方中国平凡断裂地块的内部是中等强壮的地震的主要活跃地点。在在块的西方、北的方面的断层盆地下面，上地壳被宽不连续的分布在low-velocityzone，并且在过渡带描绘从低--到高速度，中等强壮的seismicityshows活断层被开发的显域分布。NW-extensionZhoukou-Hefei-Xuancheng低速度的地区分开DabieshanMountainsand西方山东的高速度的地区--它毗邻thehigh速度地区的北方面上的安徽，和中等强壮的地震是相对经常的。这个低速度的地区可能是在北方中国和华南之间的一条重要、深深地组织的边界构造的省。(2)Thefrequent中等强壮的地震在Huoshan-Lu在过去和最近的小地震活动记录了“一个区域是在在Dabieshan的中央部分和通过外壳切了的深断裂的二个集合下面的中间的外壳中的一个低速度的地区的结果。(3)以深部构造，在安徽省的中等强壮的地震的分发有一个明显的地区性的特征。基于历史的地震复发间隔和深seismogenictectonics的类似物原则，在安徽Provinceare记录M_s5.0的潜在的地震风险地区决定了。

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简介：AbstractBackground:Oncomelania hupensis is only intermediate snail host of Schistosoma japonicum, and distribution of O. hupensis is an important indicator for the surveillance of schistosomiasis. This study explored the feasibility of a random forest algorithm weighted by spatial distance for risk prediction of schistosomiasis distribution in the Yangtze River Basin in China, with the aim to produce an improved precision reference for the national schistosomiasis control programme by reducing the number of snail survey sites without losing predictive accuracy.Methods:The snail presence and absence records were collected from Anhui, Hunan, Hubei, Jiangxi and Jiangsu provinces in 2018. A machine learning of random forest algorithm based on a set of environmental and climatic variables was developed to predict the breeding sites of the O. hupensis intermediated snail host of S. japonicum. Different spatial sizes of a hexagonal grid system were compared to estimate the need for required snail sampling sites. The predictive accuracy related to geographic distances between snail sampling sites was estimated by calculating Kappa and the area under the curve (AUC).Results:The highest accuracy (AUC = 0.889 and Kappa = 0.618) was achieved at the 5 km distance weight. The five factors with the strongest correlation to O. hupensis infestation probability were: (1) distance to lake (48.9%), (2) distance to river (36.6%), (3) isothermality (29.5%), (4) mean daily difference in temperature (28.1%), and (5) altitude (26.0%). The risk map showed that areas characterized by snail infestation were mainly located along the Yangtze River, with the highest probability in the dividing, slow-flowing river arms in the middle and lower reaches of the Yangtze River in Anhui, followed by areas near the shores of China’s two main lakes, the Dongting Lake in Hunan and Hubei and the Poyang Lake in Jiangxi.Conclusions:Applying the machine learning of random forest algorithm made it feasible to precisely predict snail infestation probability, an approach that could improve the sensitivity of the Chinese schistosome surveillance system. Redesign of the snail surveillance system by spatial bias correction of O. hupensis infestation in the Yangtze River Basin to reduce the number of sites required to investigate from 2369 to 1747.

简介：AbstractBackground:Chemotherapy plus granulocyte colony-stimulating factor (GCSF) regimen is one of the available approaches to mobilize peripheral blood progenitor cells (PBPCs). It causes thrombocytopenia and delays leukapheresis. This study aimed to evaluate the role of recombinant human thrombopoietin (rhTPO) before mobilization chemotherapy in facilitating leukapheresis in patients with lymphoma.Methods:In this randomized open-label phase 2 trial, patients were randomly assigned in a 1:2 ratio to receive mobilization with rhTPO plus GCSF in combination with chemotherapy (the rhTPO plus GCSF arm) or GCSF alone in combination with chemotherapy (the GCSF alone arm). The recovery of neutrophils and platelets and the amount of platelet transfusion were monitored.Results:Thirty patients were enrolled in this study between March 2016 and August 2018. Patients in the rhTPO plus GCSF arm (n = 10) had similar platelet nadir after mobilization chemotherapy (P=0.878) and similar amount of platelet transfusion (median 0 vs. 1 unit, P=0.735) when compared with the GCSF alone arm (n = 20). On the day of leukapheresis, the median platelet count was 86 × 109/L (range 18-219) among patients who received rhTPO and 73 × 109/L (range 42-197) among those who received GCSF alone (P=0.982). After the use of rhTPO, the incidence of platelet count <75 × 109/L on the day of leukapheresis did not decrease significantly (30.0% vs. 50.0%, P=0.297). Platelet recovery after PBPC transfusion was more rapid in the rhTPO plus GCSF arm (median 8.0 days [95% confidence interval 2.9-13.1] to platelets ≥50 × 109/L vs. 11.0 days [95% confidence interval 8.6-13.4], P=0.011). The estimated total cost of the mobilization and reconstitution phases per patient was similar between the two treatmtent groups (P=0.362 and P=0.067, respectively).Conclusions:Our findings indicate that there was no significant clinical benefit of rhTPO use in facilitating mobilization of progenitor cells, but it may promote platelet recovery in the reconstitution phase after high-dose therapy.Trial registration:This trial has been registered in Clinicaltrials.gov as NCT03014102.

简介：ThispapersummarizesthelayoutoftheYunnanseismicELFelectromagneticobservationnetwork,siteselection,ELFelectromagneticinstrumentsystem,dataprocessingandotherconstruction.TheprincipleandmethodofusingtheELFelectromagneticwavetechniquetomonitorandpredictearthquakesareexpounded.ThelongtermmonitoringofELFelectromagneticfieldsiscarriedoutintheYunnanearthquakepronearea,andatthesametime,thechangesinelectricalparametersandspatialelectromagneticfieldsoftheregionalcrustalmediumstructurearemonitored.Thefunctionssuchasautomatic,quasirealtime,remotemonitoring,networkmonitoring,dataprocessingspecialization,dataservice,datasharingandindustrializationoftheELFelectromagneticobservationdatahavebeenrealized.Inordertocapturethedeepelectromagneticprecursoryinformationoftheearthquakes,serviceforearthquakepredictionresearch,whichhasbroadapplicationprospectsanddevelopmentpotential.ThroughtheresearchoftheseismicityofYunnaninthetrialrunperiodoftheproject,thepreliminaryresultsoftheextremelowfrequencyelectromagneticobservationoftheYunnanearthquakeinrecentyearsaregiven.TheelectromagneticprecursorsandtheelectromagneticeffectsoftheYangbiearthquakearerecorded.Inthe3-monthperiodbeforetheearthquake,thepowerspectrumoftheelectricandmagneticfields,theapparentresistivityandtheimpedancephaseintheobservedsignalsareallabnormal,andgraduallyincreasedwithtime.Themaximumvalueisreached20daysbeforetheearthquake,andanearthquakeoccurswhenthechangeisrestoredtonormal.

简介：Inthispaper,weintroducetheconceptofgeneralizedg-quasi-contractionsinthesettingofconeb-metricspacesoverBanachalgebras.Byomittingtheassumptionofnormalityweestablishcommonfixedpointtheoremsforthegeneralizedgquasi-contractionswiththespectralradiusr(λ)oftheg-quasi-contractiveconstantvectorλsatisfyingr(λ)∈[0,1/s)inthesettingofconeb-metricspacesoverBanachalgebras,wherethecoefficientssatisfiess≥1.Themainresultsgeneralize,extendandunifyseveralwell-knowncomparableresultsintheliterature.

简介：AbstractBackground:Although endovascular therapy has been widely used for focal aortoiliac occlusive disease (AIOD), its performance for extensive AIOD (EAIOD) is not fully evaluated. We aimed to demonstrate the long-term results of EAIOD treated by endovascular therapy and to identify the potential risk factors for the loss of primary patency.Methods:Between January 2008 and June 2018, patients with a clinical diagnosis of the 2007 TransAtlantic Inter-Society Consensus II (TASC II) C and D AIOD lesions who underwent endovascular treatment in our institution were enrolled. Demographic, diagnosis, procedure characteristics, and follow-up information were reviewed. Univariate analysis was used to identify the correlation between the variables and the primary patency. A multivariate logistic regression model was used to identify the independent risk factors associated with primary patency. Five- and 10-year primary and secondary patency, as well as survival rates, were calculated by Kaplan-Meier analysis.Results:A total of 148 patients underwent endovascular treatment in our center. Of these, 39.2% were classified as having TASC II C lesions and 60.8% as having TASC II D lesions. The technical success rate was 88.5%. The mean follow-up time was 79.2 ± 29.2 months. Primary and secondary patency was 82.1% and 89.4% at 5 years, and 74.8% and 83.1% at 10 years, respectively. The 5-year survival rate was 84.2%. Compared with patients without loss of primary patency, patients with this condition showed significant differences in age, TASC II classification, infrainguinal lesions, critical limb ischemia (CLI), and smoking. Multivariate logistic regression analysis showed age <61 years (adjusted odds ratio [aOR]: 6.47; 95% CI: 1.47-28.36; P = 0.01), CLI (aOR: 7.81; 95% CI: 1.92-31.89; P = 0.04), and smoking (aOR: 10.15; 95% CI: 2.79-36.90; P < 0.01) were independent risk factors for the loss of primary patency.Conclusions:Endovascular therapy was an effective treatment for EAIOD with encouraging patency and survival rate. Age <61 years, CLI, and smoking were independent risk factors for the loss of primary patency.

简介：XinhuaNewsAgency,Beijing,March25OnMarch25,MinistryofEducationissuedNoticeoftheStateCouncilDegreeCommitteeonSpecialEvaluationResultofDegreeConferralInstitutionsandRelevantHandlingOpinionsin2014.TheNoticestipulates