简介:AIM:Toexaminethemechanismofthedevelopmentofpseudoexfoliation(PSX)syndromeviabothcytokineformationandendothelialvasorelaxingandgrowthfactorsthatwillprovideusnewtherapeuticinsightsforthetreatment.METHODS:Thisisacrosssectionalstudyincludedtwogroups;Group1:controlpatientswithnuclearcataract(n=20,aged51-80years).Group2:PSXpatientswithnuclearcataract(n=18,aged50-90years).Patientswithotherophthalmicproblemsandsystemicdiseaseswereexcluded.Vascularendothelialgrowthfactor(VEGF),interleukin-6(IL-6)andinterleukin-1β(IL-1β)andnitrotyrosinelevelsweredeterminedthroughserumsamplesbyEnzyme-linkedimmunosorbentassay(ELISA)method.Nitrite-nitratelevelsweremeasuredwithphotometricendpointdetermination.RESULTS:Therewerenosignificantdifferencesbetweenthegroupsintermsofage,VEGF,IL-1β,nitrite-nitrateandnitrotyrosine.ThesignificantresultswerethemeanIL-6levelsthatwerehigherinPSXgroup2(37.68±29.52pg/mL)comparedtothatincontrolgroup1(15.32±10.08pg/mL)(P<0.001).CONCLUSION:SeveralinteractingandextendingbiochemicalpathwaysmayleadtothepromotionofVEGFandIL-6expressions.IL-6whichistheonlyalteredmarkerinourstudymayindirectlycauseanincreaseofvascularpermeabilityandneovascularization.WesuggestinflammationasafactorthatcanbeinvolvedinetiopathogenesisofPSX.
简介:目的探讨可调节缝线技术应用于小梁切除术的临床疗效。方法对92例(107只眼)原发性闭角型青光眼,随机分为两组;观察组(A组)48例56只眼行可调节缝线小梁切除术;对照组(B组)44例51只眼行传统小梁切除术。观察比较术后前房、眼压、住院日等情况。结果术后一周内浅前房的发生率观察组为16.1%(9只眼),对照组为31.4%(16只眼);术后半年,眼压的控制两组无明显差异(P〉0.05);平均住院日观察组小于对照组,差异有显著性(P〈0.05)。结论小梁切除术联合应用可调节缝线技术,可减少术后早期浅前房的发生,增加手术安全性,缩短平均住院日,但对眼压的长期控制并不优于传统的小梁切除术。
简介:目的:探讨裂隙灯眼前段处理系统在眼科临床工作中的各种实际应用状况及操作技巧。方法:应用配置佳能PowerShotA720IS型数码照相机(1200万像素)SLM型裂隙灯显微镜检查眼部病变情况,并在裂隙灯下根据不同的病变位置,在不同色彩、角度下进行照相(放大倍率×10;×16;×20)。结果:采集不同种类疾病具有代表性照片:眼睑及结膜肿物、结膜裂伤、角膜炎、角膜异物、翼状胬肉、前房积血、前房角异物等如图示。结论:裂隙灯眼前段处理系统的应用为临床医疗文献提供直接定性依据,给患者了解自身病情带来便利,照片直观、经济,在眼科领域的临床应用具有广阔的前景。
简介:Endogenousaspergillusendophthalmitis(EAE)afterkidneytransplantisararebutimportantclinicalproblemduetopotentiallydevastatingconsequences.EarlydiagnosisofEAE,timelyremovalofaffectedvitreousbyvitrectomy,properanti-fungaltreatment,allcontributedtothesuccessfulcontrolofthedisease.TherapeuticsuccessofEAEinpost-transplantpatientsdependslargelyonpromptdiagnosis.DefinitediagnosisofEAEisbasedonpositivecultureresultsofvitreousspecimen,whilefundoscopyandBscanultrasoundmayaidearlydiagnosis.Intermsofanti-fungalmedicine,amphotericinBhaslongbeenthefirstchoice,butitssystemicapplicaitonhassevereadversereactions,especiallyforpatientswithimpairedrenalfunction.Herein,wereportthetreatmentmodalityofEAEafterkidneytransplantwithvitrectomy,systemicadministrationofmicafunginplusvoriconazole,topicalapplicationoffluconazolandamphotercinB.