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简介：BACKGROUND:Thestellateganglionblock(SGB)playsaprotectiveroleinfocalcerebralischemia/reperfusioninjury.ThehumanSGBcanbesimulatedbytransectionofthecervicalsympathetictrunk(TCST)inrats.OBJECTIVE:ToobservetheeffectsofTCSToninduciblenitricoxidesynthase(iNOS)levelsandcerebralinfarctvolumeinthehippocampusofratswithcerebralischemia/reperfusioninjury,andtoanalyzethemechanismofaction.DESIGN,TIMEANDSETTING:Acompletelyrandomized,controlled,neuropathologicalexperimentwasperformedattheInstituteofNeurologicalDisease,TaiheHospital,YunyangMedicalCollegebetweenMarchandSeptember2006.MATERIALS:Atotalof93Wistarrats,aged17-18weeks,ofeithergender,wereusedforthisstudy.2,3,5-triphenyltetrazoliumchloridewaspurchasedfromChangshaHongyuanBiologicalReagentCompany,China.RabbitiNOSantibodyandgoatanti-rabbitIgGantibodyweretheproductsofWuhanBosterBiologicalReagentCo.,Ltd.,China.METHODS:Tenratswererandomlyselectedforthesham-operatedgroup.Cerebralischemia/reperfusioninjurywasinducedbymiddlecerebralarteryocclusion(MCAO)usingthesuturemethodintheremainingrats.Fortysuccessfulratmodelswererandomlyandequallydividedintothefollowingtwogroups:(1)TCSTgroup:subsequenttoTCST,MCAOwasperformedfor2hours,followedby24hoursreperfusion;(2)modelgroup:ratsunderwentexperimentalproceduressimilartotheTCSTgroup,withtheexceptionofTCST.Ratsinthesham-operatedgroupweresubjectedtoexperimentalproceduressimilartothemodelgroup;however,thethreadwasonlyintroducedtoadepthof10mm.MAINOUTCOMEMEASURES:Following24hoursofreperfusion,functionalneurologicaldeficitswerescored.BraintissuesectionsfromtenratsofeachgroupwereusedtomeasurecerebralinfarctvolumebyTTCstaining.HippocampaltissuesectionsofanadditionaltenratsfromeachgroupwereusedtodetectiNOSlevelsusingthestreptavidin-peroxidaseimmunohistochemis

简介：瞄准：为了调查白果树biloba的效果，肺损害上的摘录(EGb761)由肠的ischemia/reperfusion(II/R)导致了。方法：II/R损害的老鼠模型被为灌注为180min跟随的60min夹钳优异mes伤寒动脉生产。老鼠随机被分配进假冒，II/R，和EGb+II/R组。在EGb+II/R组，EGb761(100mg/kg每天)在外科以前经由一个胃的试管被给7连续的天。在II/R和假冒的组的老鼠与EGb761的车辆的相等的体积被对待。肺损害被轻显微镜学，wet-to-dry肺重量比率(W/D)和肺的渗透索引(PPI)估计。malondialdehyde(MDA)和亚硝酸根/硝酸盐的层次(没有(2)(-)/NO(3)(-))，以及超级氧化物歧化酶(草皮)的活动和myeloperoxidase(军邮局)被检验。西方的污点被用来决定可诱导的氮的氧化物synthase(iNOS)的表示。结果：显著地改进的EGb761意味着动脉压和稀释的肺损害，由组织学的变化的改进和肺的W/D和PPI的重要减少表明了(P<0.05或0.01)。而且，EGb761显著地增加了草皮活动，减少的MDA层次和军邮局活动，并且没压制iNOS表示的下面规定伴随的产生(P<0.05或0.01)。结论：结果显示EGb761在II/R导致的肺损害上有保护的效果，它可能与它的抗氧化剂性质和嗜中性的累积的抑制有关并且导致iNOS没有产生。EGb761似乎是为有与II/R有关的呼吸衰竭的非常有病的病人的一个有效治疗学的代理人。

简介：Objectives:Toinvestigatetheeffectsofadenovirus-mediatedinduciblenitricoxidesynthasegenetransfectiononbladdertransitionalcellcarcinomaT24cells,andtoprovidenovelinsightsandapproachestoclinicaltherapiesagainstbladdertransitionalcellcarcinoma.Methods:Firstly,constructrecombinantadenovirusvectorpAd-iNOSofiNOS,followedbytransfectionofpAd-iNOSintoHECK293packagingcells.Thirdly,harvestrecombinantadenovirusrAd-iNOSafteramplificationandpurificationprocedures.Finally,transfecttherecombinantadenovirusrAd-iNOSintohumanbladdercarcinomaT24cellsandexaminetheeffectofrAd-iNOStransfectiononapoptosisofT24andpossiblemechanism.Results:Asshownbythisstudy,therecombinantadenovirusrAd-iNOSwasconstructedsuccessfully.Thevirustiterwas5.8×108PFU/mLandrecombinantwasverifiedbyPCRanalysis.TransfectionofadenovirusrAd-iNOSintoT24cellscouldinducesecretionofhighNOconcentration,P53proteinexpressionupregulation,aswellaspromotionofT24cellapoptosis.Conclusions:ThetransfectionofhumanbladdercarcinomaT24cellsfromrecombinantadenovirusrAdiNOSwasconfirmedtoinduceintracellulariNOSover-expression,highproductionofNO,up-regulationofintracellularP53expressionandpromotionofcellapoptosis.

简介：氮的氧化物(没有)在neurodegeneration的提升被含有。然而，很少对在之间的关系被知道没有并且在neurodegenerative的神经干细胞(NSC)的自强或区别能力疾病。在这研究，我们调查了效果不，在在一个动物的NSC的自强上，为Niemann精选的模型打C(NPC)疾病。我们发现没有生产显著地从NPC1缺乏的老鼠(NPC1-/-)在NSC被增加，它显示出减少的NSC自强。nestin积极的房间的数字和neurospheres的尺寸显著地两个都被减少。没有synthase(NOS)的表达式在与野类型的neurospheres相比从NPC1-/-鼠标的大脑导出的neurospheres被增加。肝糖synthasekinase-3beta(GSK3beta)和caspase-3的不调停的激活也从NPC1-/-老鼠在NSC被观察。从NPC1-/-老鼠的NSC的自强能力被一个NOS禁止者恢复，L名字，它导致了GSK3beta和caspase-3的抑制。另外，NSC的区别能力部分被恢复并且Fluoro碧玉的数字C积极的堕落神经原被减少。这些数据建议那生产过剩不，在NPC，疾病损害了NSC的自强。没有生产的控制可能为NPC疾病的处理是关键的。

简介：Anovelfluorescentprobe9-(4-(1,2-diamine)benzene-N1-phenyl)acridine(DABPA)wassynthesizedforthedetectionofnitricoxide(NO)andcharacterizedbyIR,1H-NMRandEI-MSspectroscopy.Basedonaphotoelectrontransfermechanism,thefluorescenceintensitiesofDABPAwereinvestigatedwiththedifferentconcentrationsofNO.Undertheoptimalexperimentalconditions,thefluorescenceintensityofDABPAhadagoodlinearrelationship(R2=0.9977)withNOconcentrationintherangefrom1×10-7to1.5×10-6mol/Lwithadetectionlimitof1×10-8mol/L.ThecytotoxicityinducedbyDABPAwasevaluatedbytheMTT(3-(4,5-dimethylthiazol-2-yl)-2,5diphenyltetrazoliumbromide)assayforbiologicalapplication.Furthermore,theprobeDABPAhadalsobeensuccessfullyappliedtoreal-timeimageNOproducedinPC12cellsinthepresenceofL-arginine.

简介：Inthepresentstudy,aseriesofnovelnitricoxide-hydrogensulfidereleasingderivativesof(S)-3-n-butylphthalide((S)-NBP)weredesigned,synthesized,andevaluatedaspotentialantiplateletagents.CompoundNOSH-NBP-5displayedthestrongestactivityininhibitingthearachidonicacid(AA)-andadenosinediphosphate(ADP)-inducedplateletaggregationinvitro,with3.8-and7.0-foldmoreeffectivenessthan(S)-NBP,respectively.Furthermore,NOSH-NBP-5couldreleasemoderatelevelsofNOandH2S,whichwouldbebeneficialinimprovingcardiovascularandcerebralcirculation.Moreover,NOSH-NBP-5couldrelease(S)-NBPwhenincubatedwithratbrainhomogenate.Inconclusion,thesefindingsmayprovidenewinsightsintothedevelopmentofnovelantiplateletagentsforthetreatmentofthrombosis-relatedischemicstroke.

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简介：Theexfoliationdegreeofgraphiteoxideintographeneoxideplaysanimportantroleinthemassiveproductionmethodofreducedgrapheneoxide.Itissignificanttofindasimpleandfeasiblemethodtoanalyzetheexfoliationdegreeofgraphiteoxide.Inthepresentwork,graphiteoxidewassynthesizedbyamodifiedHummersmethod,andthengrapheneoxidecolloidswereobtainedbyexfoliationofgraphiteoxidedispersedinde-ionizedwater.UV-visiblespectroscopywasusedtocharacterizetheabsorptionofthegrapheneoxidecolloids,andtheconcentrationofgrapheneoxidecolloidsindicatedbyabsorptionareaofUV-visiblespectrawasstudied.Resultsshowthatthereisarelativelystablerelationshipbetweenthem,indicatingthatUVvisiblespectroscopyisapotentialmethodforanalyzingtheexfoliationdegreeofgraphiteoxideintographeneoxide.

简介：OxidemetallurgytechnologyhasbeendevelopedatBaosteelforimprovingtheheataffectedzonetoughnessofsteelplatesforhighheatinputwelding.AfterdeoxidationwithstrongdeoxidizersofMgalloy,thecomplexinclusionscontainingpartsofcompoundsofMgO,Ti2O3,MnO,Al2O3,MnS,CaSandTiNareformed.Thesekindsofinclusionsarebeneficialforpromotingtheformationofintragranularferrite.Aftertwo-electrodevibratoryelectrogasarcweldingwiththeV-typegrooveandahighheatinputof395kJ/cminasinglepass,theformeraustenitegrainisveryfineinsize,withanaveragegrainsizeofonly85μm.Excellentheataffectedzonetoughnessisobtainedforthedevelopedsteelplateswithathicknessupto68mm.

简介：Modifieddiphenyloxideresinwassynthesizedbyco-polymerizationofunsaturatedacidanddiphenyloxidederivants.Andthenmodifiedbismaleimideresinandexpoxidelinearphenolicresinwereaddedintomodifieddiphenyloxideresintoco-polymerizeandmodifyoncemore.Thesystemwasappliedincomposites.Theirpropertieswereinvestigatedandfoundthattheymettherequirementsasaheat-resistingadhesive.

简介：Meltsofleadbismuthgallatecompositionsarehighlycorrosiveandattackoncruciblesofdifferentmaterials.Inthepresentstudy,corrosionbyabaseglass(50PbO-30Bi2O3-20Ga2O3inmolefraction)meltedusingdifferentcruciblesandtheeffectonUV-VISandIRedgeswerestudied.Bymeltingthebaseglassinplatinum/2%rhodium,goldzirconiaandaluminacruciblesshowedlesseffectontheIRedgeandthereforeshiftedtheinfrarededgetolongerwavelength,whereassilicacruciblecontaminatedtheglass,causingaseveredeteriorationintheinfraredandhenceshiftedinfrarededgetomuchshorterwavelength.IntheUV-VISregion,baseglassmeltedinplatinum/2%rhodiumcrucibleshiftedtheedgetothelongestwavelengthwhereassilicacrucibleshiftedtheedgetoshorterwavelength.Thecontaminantsfromgold,zirconiaandaluminacruciblescausedtheUV-VISedgeofthebaseglasstoliebetweenthetwoextremesofPt/2%RhandSiO2crucibles.Theglassesmeltedinabovementionedcrucibleswerealsocharacterizedwithinductivelycoupledplasmaspectroscopy(ICP)analysistomeasurethelevelofcontaminationfromthecrucibles.Dependinguponcrucibleused,thecolorsofglassesobtainedrangedfromredtoyellow.

简介：Aim:Tostudytheeffectofdiabetesmellitusandinsulintreatmentonratpenilenitricoxidesynthasecontent.Methods:MaleWistarratsweredividedatrandomintotwogroups:theControl(n=8)andtheDiabetic(n=17).Diabetesmellituswasinducedbyintraperitonealinjectionofstreptozotocin.Thediabeticanimalswerethenrandomlydividedintotwosubgroups:diabeticratswithoutinsulintreatment(n=7)anddiabeticratswithinsulintreatment(n=10).Theneuronalnitricoxidesynthase(nNOS)inthepenilecorpuscavemosumwereassayedbyimmumohistochemicalstainingwithspecificantibodytonNOSandthenNOS-positivenervefiberswerecountedsemiquantitativelyunderahighpowermicroscope.Results:ThenNOS-positivenervefibresindiabeticratswithtreatmentwashigherthanthatindiabeticratswithouttreatment(P<0.05)andlowerthanthatinthecontrols(P<0.01).ThenNOS-positivenervefibresindiabeticratwithouttreatmentwerealsolowerthanthatinthecontrols(P<0.01).Conclusion:Instreptozotocin-induceddiabeticrats,thenNOScontentinthepenilecorpuscavemosumwassignificantlydecreased.InsulintreatmentatthedoselevelemployedpartiallyrestoresthepenilenNOScontentintheserats.

简介：OnApril20,2009thecontractonfabricationofanEOreactorincludedintheprojectforrevampoftheEOreactionsystematSINOPECYangziPetrochemicalCompanywas

简介：磁铁矿(Fe3O4)nanotubes被减少综合赤铁矿准备(在5%H2+95%Ar空气的-Fe2O3)nanotubes，然后磁赤铁矿(-Fe2O3)nanotubes被重新氧化获得Fe3O4nanotubes。nanotube结构被不崩溃或在整个减少的高温度和重新氧化的过程的sintering。Fe3O4和-Fe2O3nanotubes的coercivities综合了与一样的阶段并且类似的尺寸比另外的nanostructures高两个都被发现分别地，是340.22Oe和342.23Oe。吸附的磷酸盐和nanotube结构为这高coercivity被认为负责。

简介：抵抗切换(RS)行为为数据存储由于他们的有希望的潜力吸引了大兴趣。在各种各样的材料之中，基于氧化物的设备看起来就他们有互补金属氧化物半导体技术的方便制造和相容性而言更有益，尽管内在的机制由于RS行为的差异仍然是争论的。在这评论，我们集中于基于氧化物的RS记忆，工作机制能根据一个所谓的细丝模型的意见基本上在被理解。细丝形成/破裂进程，途径发展了检测并且描绘细丝，在基于氧化物的抵抗随机改进RS和量传导力行为的表演的几次有效尝试存取存储器(RRAM)设备分别地被探讨。

简介：ＬａｓｅｒＴｒｅａｔｍｅｎｔｏｆＯｘｉｄｅＤｉｓｐｅｒｓｉｏｎＳｔｒｅｎｇｔｈｅｎｅｄＡｌｌｏｙｓＳｈａＷｅｉ（沙维）（ＤｅｐａｒｔｍｅｎｔｏｆＭａｉｅｒｉａｌｓＳｃｉｃｎｃｅａｎｄＭｅｔａｌｌｕｒｇｙ，ＵｎｉｖｅｒｓｉｔｙｏｆＣａｍｂｒｉｄｇｅ，Ｕ...

简介：Industrialapplicationofmicrowave,asaheatingsourceformaterialprocessing,wasreviewed.Thefeasibilityofcarbothermicreductionofzincoxideconcentrate,aswellastheeffectofoperatingparameterswasinvestigated,usingahomestylemicrowaveovenat2.45GHz.Zincoxideconcentratedoesnoteffectivelyabsorbmicrowaveenergy,whileanysourceofcarbon,whichisusedasthereductionagent,absorbsmicrowaveenergyverywell.Inthisrespectcokebreezewasfoundtobethebest,andthus,cokewasusedbothasthereducingagentandtheabsorbentofmicrowaveenergy.Itwasalsofoundthatanyincreaseinthecarboncontentandsize,increasesthereductionrate.Increasingthemicrowavepowerandthesizeofthesamplecouldalsoincreasethereductionrate.Furtherinvestigationshowsthatwhenzincoxideisexposedtothemicrowaveforsometime,therateofthereductionbyconventionalmethodincreases.

简介：Strontium-zinc-oxide(SrZnO)filmsformingthesemiconductorlayersofthin-filmtransistors(TFTs)aredepositedbyusingion-assistedelectronbeamevaporation.Usingstrontium-oxide-dopedsemiconductors,theoff-statecurrentcanbedramaticallyreducedbythreeordersofmagnitude.Thisdramaticimprovementisattributedtotheincorporationofstrontium,whichsuppressescarriergeneration,therebyimprovingtheTFT.Additionally,thepresenceofstrontiuminhibitstheformationofzincoxide(ZnO)withthehexagonalwurtzitephaseandpermitstheformationofanunusualphaseofZnO,thussignificantlychangingthesurfacemorphologyofZnOandeffectivelyreducingthetrapdensityofthechannel.