简介：目的：观察电针治疗急性腰扭伤的，临床疗效以及治疗前后腰部红外热像图的变化。方法：采用随机数字表将295例急性腰扭伤患者随机分为电针组147例和药物组148例，电针组选用后溪穴治疗，药物组用美洛昔康片治疗，各组治疗前后进行腰部红外热像图的检查。结果：电针组和药物组痊愈率分别为71．4％和42．6％；有效率分别为93．9％和87．2％（P〈0．01）；电针组与药物组红外热像图治疗前后温度差分别为为2．52℃和0．80℃（P〈0．01），二者有显著性差异。结论：电针组和药物组治疗急性腰扭伤均有显著疗效，但电针组的总体疗效优于药物组，且电针组治疗前后红外热像图的升温效应也明显高于药物组。

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简介：Incomparisonwiththenormalpeoplegroup,valuesofbloodCD2+andCD4+inpa-tientswithmallgnanttumorstreatedwithradiotherapyandchemotherapyweresignificantlylowerandtheratioofCD助+andCD8+decreasedobviously（allP<0.001）;CD8+hadnoapparentchange（P>0.05）.Followingacupuncturaltreatment,valuesofCD2+,CD4+andtheratioofCD4+toCD8+increasedobviously（allP<0.001）;whilethoseofthemedicinalcontrolgrouphadnosignificantchangeaftertreatment（P>0.05）.ValuesofIgG,IgAandIgMinpatients’serumpresentedanabnormalde-creasingorincreasingtendency,andC3inminorityofpatientswereraised.ResultsindicatedthattherewasabiphasicregulatoryeffectofacupunctureonthedisturbanceofhumoralimmunityandcouldcorrectthedeviationofC3level;anditseffectwasbetterthanorsimilartothatofthemedicinecontrolgroup.Itdemonstratesthatacupuncturecanenhanceandregulate.theimmunefunctionofpa-tientstreatedwithradiotherapya

简介：Aim:Tostudytheeffectofprothymosinα(ProTα)asafusionproteinonthesecetionofINF-γ,IFN-αandTNF-αinvitro.Methods:Theinvitrostudywascarriedoutontheculturedofsplenocytes,splenicandperitonealmacrophagesisolatedfromBalb/cmice.SplenocyteswereincubatedwithvariousconcentrationsofProTα(1×10^-7-1×10^-10mol·L^-1)withorwithoutConA(5μg·mL^-1)for72h.SplenicandperitoealmacrophageswererespectivelytreatedwithProTα(1×10^-7-1×10^-10mol.L^-1)inthepresenceofLPS(10μg·mL^-1)for24h.ThenINF-γ′s,INF-α′sandTNF-α′slevelsinthesupernatantweredetecedbyELISA,Results:ProTα(1×10^-7)mol.L^-1)wasfoundtoobviouslyincreaseINF-γlevel(P<0.05)inthesupernatantofsplenocytescomparedwiththecontrolgroup.Moreover,ProTα(1×10^-7mol.L^-1)significantlyinducedthesecretionofINF-α(P<0.01)andTNF-α(P<0.01)insplenicandperitonealmacrophages.Conchusion:Invitro,ProTαcouldincreasethesecretionofIFN-γ,IFN-αandTNF-α.

简介：Wnt-1induciblesignalingpathway-1(WISP-1),alsoknownasCCN-4,belongstotheconnectivetissuegrowthfactor(CTGF)family.WISP-1isprimarilyexpressedinembryonicstemcellsandisinvolvedinadultorgandevelopment.WISP-1participatesinmanycellularprocesses,includingproliferation,differentiation,apoptosisandadhesion.Inaddition,WISP-1playsanimportantroleindiversepathophysiologicalprocesses,suchasembryonicdevelopment,inflammation,injuryrepairsandcancers.RecentstudiesshowedthatWISP-1washighlycorrelatedwithtumorprogressionandmalignanttransformation,whereasitplayedanoncogenicroleincolorectalcancer,cholangiocarcinoma,hepatocellularcarcinomaandbreastcancer.However,interestingly,WISP-1exertsatumorsuppressingroleinlungandprostatecancers.WISP-1promotescellproliferation,adhesion,motility,invasion,metastasisandepithelial-to-mesenchymaltransitionviaparticularsignalingpathways.Inthisreview,wediscussedthestructure,expressionprofile,functions,clinicalsignificanceandpotentialmechanismsofWISP-1incancerandnon-neoplasticdiseases.

简介：Tocleanoutthesmearlayeronteethsurface,andprotecttheteethmedulla,theexperimentappliedthestudyobservingthecleanupofsixgroupsofsurfacesmearlayerofdentalcariesandthetubuleplugsreservingeffectafterusingofdifferentcavitycleanserswiththehelpofSEM.Theresultimpliedthatboththeacidicpreparationsandchelatorcouldcleanoutthesmearlayeron.teethsurfaceinsomeway,butthelateronecouldalsoreservepartialtubuleplugs,whichreducethestimulationtotheteethmedulla.Sothechelatorisbettercleansersinclinicaluse.

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简介：将中风偏瘫患者分为针灸结合康复训练组(n=50),针灸组(n=32),康复训练组(n=31),采用针刺治疗和康复训练.在治疗前后对患者偏瘫肢体的运动功能和日常生活能力进行评定.总有效率针灸结合康复训练组明显高于针灸组和康复训练组(P＜0.01),而针刺组和康复组的总有效率比较无明显差异(P＞0.05).针灸结合康复训练是治疗中风偏瘫的有效方法.

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简介：Objective:Toanalyzequantitativelythesynergisticandantagonisticeffectsofcombinedoxymatrine(OMT)and5-fluorouracil(5-GU)onacelllineofhumanlivercancer(HepG2)withmedian-effectprincipleinvitro.Methods:Themedian-effectprincipleandMTTmethodwereusedinthequantitativeanalysisofeffectsofthetwodrugs.Results:Cytotoxicactivityoftheindividualdrugsenhancedasdrugconcentrationincreased.Asfa=0.41,aCIequalto1indicatedadditivity;fa<0.41,aCIlessthan1indicatedsynergy;andfa>0.41,aCIgreaterthan1indicatedantagonism.Thesequenceofadministrationdidnotinfluencethecytotoxicactivityofthecombinedantitumordrugs.Theratioofdrugconcentrationwasafactorthatcaninfluencethekillingeffect.Conclusion:Thecombineddrugsinteraction(CI<1)wassynergisticatlowerconcentrationandantagonisticathigherconcentration.Theratioofdrugconcentrationisafactorthatcaninfluencethekillingeffect.

简介：Objective:ToconfirmwhetherBungarusmulticinctuscrudevenominducestheapoptosisofK562tumorcellsandtofindoutthecomponentsinducingapoptosisofK562cellsfromthecrudevenom.Methods:thecrudevenomseparatedandpurifiedbycationexchangechromatography,andtheeffectofvenomsonK562wasstudiedbyMTTmethodandflowcytometry.Results:ThecrudevenombegantokillK562cellsatthan8(103ng/ml(thesurvivalratewas82.5%)concentrationandtheeffectwasmoresignificantin24hwhenadministrating8(105ng/ml(thesurvivalratewas29.4%)crudevenom.ApoptoticbodieswereobservedintheK562tumorcellsbyfluorescentmicroscopyafteradministrationof5(g/mlcycloheximide(CHX)orthepeakVIsolutionatabout8(105ng/ml.Thesameresultsweredetectedbytheflowcytometry.Asub-G1peakappearedafteradministrationofCHXorthesixthpeaksolution.Conclusion:TheauthorsfoundthatthevenomcankillK562tumorcellsintime-anddose-dependentmanner.However,thekillingeffectofthevenomisnotapoptosis.What'smore,thepeakVIsolution,acomponentofthecrudevenomcaninducetheapoptosisofK562tumorcells.

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简介：AbstractThe effects of gestational diabetes mellitus (GDM) on offspring include macrosomia, hypoglycemia, respiratory distress syndrome, cardiovascular disease, neural and mental injury, etc. The effects of GDM on the health status of offspring are sustained although pregnancy has ended. It has been proposed that fetal reprogramming causes long-term consequences to metabolic health in offspring. An intrauterine high-glucose environment may lead to changes in the multi-differentiation proficiency of intracorporal stem cells, showing decreased proliferation and osteogenic ability, increased adipogenic ability, accelerated apoptosis, and occurrence of premature failure. This environment also reduces the mobilization of bone marrow stem cells, whereas it increases that of medullary cells. This results in pro-inflammatory conditions and sustained inflammation in the body, thereby increasing the risk of obesity, cardiovascular and neurological disorders, and metabolic abnormalities. Stem cells derived from the amniotic membrane, umbilical cord, or placenta may be a reliable predictor of the long-term effects of GDM on offspring. The levels of blood glucose during pregnancy should be effectively controlled to reduce harm to the neonate.

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简介：Objective:Toobservetheeffectofacupunctureonsimpleobesityandcellularhemorheology.Methods:Thirty-twocasesofsimpleobesitypatientswereenrolledintothisstudy.AcupointsoftheStomachMeridianandSpleenMeridianasZhongwan(中脘CV12),Liangmen(梁门ST21),Tianshu(天枢ST25),Guanyuan(关元CV4),etc.werepunctured,oncedailyinthefirst5days,andonceeveryotherdayafterwards,with10sessionsbeingatherapeuticcourse.Beforetreatmentandafter3coursesoftreatment,thebodyweight,waistline,weightindex,serumcholesterol(CH),triglycerideandaggregationindexofredbloodcell(RBC)weredetected.Results:Afteracupuncturetreatment,alltheindexesofbodyweight,waistline,weightindex,serumCH,triglycerideandaggregationindexofRBCdecreasedsignificantlyincomparisonwiththoseofpre-treatment(P<0.05).Conclusion:Acupuncturecanapparentlyimprovecellularhemorheology,reducebodyweight,serumcholesterolandTGlevelsinsimpleobesitypatients.

简介：SincetheinventionofRubylaserbyMaimanin1960s,manykindsoflasersareusedwidelyindentistry.Ithasbeenprovedthatlaserirradiationcanproduceacidetchinglikesurface,thusstrengthenthebondofmaterialtoenamel.Buttheheatgeneratedduringirradiationproducesdamageondentalpulp,whichlimitsthelaserapplicationsondentalhardsurfaces.

简介：目的：研究针刺对中风偏瘫痉挛状态的影响。方法：采用修改的Ashworth痉挛评定级、Brunnstrom分级、Barthel日常生活能力（ActivitiesofDailyLiving，ADL）指数分别评定痉挛程度、运动功能水平、日常生活能力，观察头针、体针联合应用对中风后偏瘫患者痉挛状态的影响。结果：头针、体针联合应用对痉挛状态的改善，对运动功能水平及日常生活能力的影响均优于单纯体针治疗（P〈0．01）。结论：头针、体针联合应用在改善痉挛状态方面有独特的优势，可提高患者的运动功能水平及日常生活能力。

简介：ＳＴＵＤＩＥＳＯＮＴＨＥＧＡＰＪＵＮＣＴＩＯＮＡＬＩＮＴＥＲＣＥＬＬＵＬＡＲＣＯＭＭＵＮＩＣＡＴＩＯＮＯＦＨＵＭＡＮＮＡＳＯＰＨＡＲＹＮＧＥＡＬＣＡＲＣＩＮＯＭＡ　ＣＥＬＬＳＡＮＤＴＨＥＥＦＦＥＣＴＯＦＲＩＩＨａｎＬｉｑｕｎ韩立群；ＧａｏＪｉｎ高进；...