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简介:Theassessmentofthewave-inducedsoilliquefactionplaysakeyroleinthegeotechnicaldesignforoffshorefoundations.Theunderlyingshortcomingsoftheexistingmomentaryliquefactioncriteriaareidentifiedandclarifiedbymechanismanalysesandtherecentfieldobservations.Amodifiedcriterionforthewave-inducedmomentaryliquefactionofasandyseabedisgiventodescribetheverticalporepressuredistributions.Animprovedapproximationofthemomentaryliquefactiondepthisfurtherpresented.Parametricstudyoftheeffectsofthesaturationdegreeofsoilsindicatesthatthismodificationissignificantfortheevaluationofwave-inducedmomentaryliquefaction.
简介:瞄准:在老鼠把芙蓉sabdariffa(Roselle)和姜officinale(生姜)的保护的效果与导致cisplatin的繁殖毒性作比较并且学习位于这些效果下面的机制。方法:H.sabdariffa或Z.officinale(1g/kgx天)的乙醇摘录被给p.o到男白鼠26天,它在单个cisplatini.p注射(10mg/kg体重)前开始了21天。结果:H.sabdariffa和Z.officinale的摘录减少了导致cisplatin的精子反常的程度并且提高了精子活动性。两篇摘录恢复了malondialdehyde(MDA)的控制水平(类脂化合物每氧化标记)在对待cisplatin的睾丸。导致的cisplatin注射在超级氧化物的层次衰退歧化酶(草皮),减少的谷胱甘肽(GSH)和过氧化氢酶(猫)显著地被颠倒在cisplatin被H.sabdariffa或Z.officinale的管理先于的组控制层次。结论:H.sabdariffa和Z.officinale处理增加了阴囊的抗氧化剂酶的活动并且恢复了对待cisplatin的老鼠的精子活动性。因此,测试植物的保护的效果被建议被他们的有势力抗氧化剂活动调停。
简介:Thisstudydemonstratesanovelapproachforrapidsynthesisofsilver(Ag)nanowiresinducedbyvanadiumtrioxide(V2O3)particlesinaqueoussolutionatroomtemperature.Silvernanowireshaveanaveragediameterof20nmandlengthuptoafewmicrometersbyparametricoptimization.ThemicrostructureofthesilvernanowireswascharacterizedbyTEM,HRTEM,SEM,andXRDtechniques.Theopticalpropertyoftheas-preparedproductwasmeasuredbyultraviolet-visible(UV-vis)spectroscopy.ThepossiblegrowthmechanismofAgnanowiresviaorientedattachmentofAgnanocrystalswasdiscussed.Thepresentapproachshowsseveraluniquefeaturessuchasrapid(afewminutes),reproducibleandhigh-yieldreactionwithnoneedofanymodifiers.V2O3rodswerereportedforthefirsttimetobeusedforsynthesisofsilvernanowires,playingmultiplerolesasreducingagent,template,andcatalyst.Thesilvernanowiresproducedarepromisingforopticalapplications(e.g.,SERS)duetotheirroughsurface.
简介:Thispaperintroducesthebasickineticandthermodynamicfactorsaffectingstep-bunchinginstabilityandderivetheone-dimensional(1D)stepmotionequationbasedadatomdiffusionequationforfurtheranalysis.Thestep-bunchinginstabilityisanalyzedfordifferentcases.
简介:AbstractObjective:To investigate the expressions of MAPK10, c-Jun and Itga6 in laryngeal carcinoma and its influence on the sensitivity to docetaxel, cisplatin and 5-fluorouracil (TPF) chemotherapy.Methods:Fifty-seven patients with supraglottic squamous cell carcinoma, who were treated by two cycles of TPF induction chemotherapy in our hospital, were enrolled in this study and divided into groups by chemotherapy resistance or chemotherapy sensitivity. The expressions of mRNA and protein of MAPK10, c-Jun and Itga6 in tumor tissues were evaluated by immunohistochemistry. The consistency of mRNA and protein expressions was tested, and the relation with the clinicopathological features was analyzed.Results:The positive rates of MAPK10 andc-Jun in the tumor tissues of the sensitive group were significantly higher than those of there assistant group, which was 90.48% and 100.00%, respectively. The expression rate of Itga6 was significantly higher in the resistant group, which was 83.33% (P < 0.05). The mRNA levels of MAPK10 and c-Jun were significantly lower in the resistant group than in the sensitive group, whilethemRNA levelof Itga6was significantly higher in the resistant group (P < 0.05). The protein expressions of MAPK10, c-Jun and Itga6 were consistent with their mRNA expressions (P < 0.05). The expressions of MAPK10, c-Jun and Itga6 were not correlatedwithage, gender and tumor diameter (P > 0.05). However, the expressions of MAPK10 and c-Jun were negatively correlated withclinical stage and pathological grading (P < 0.05). Negative correlations between MAPK 10 and Itga6, and between c-Jun and Itga6in tumor tissues were found by Spearman’srank correlation coefficient (P < 0.05). The correlation was also negative in the resistant tumor tissues (P < 0.05).Conclusion:The MAPK10 and c-Jun expressions were down-regulated, while the Itga6 expression was up-regulated in the chemo-resistant laryngeal carcinoma, and the expression levels of different factors were correlated witheach other. These factorsmight be important biomarkers for predicting outcomes of TPF chemotherapy in laryngeal carcinoma in the future.
简介:AtheoreticalinvestigationonthepH-inducedswitchingofmixedpolyelectrolytebrusheswasperformedbyusingamoleculartheory.TheresultsindicatethattheswitchingpropertiesofmixedpolyelectrolytebrushesaredependentonthepHvalues.AtlowpH,negativelychargedchainsadoptacompactconformationonthebottomofthebrushwhilepositivelychargedchainsarehighlystretchedawayfromthesurface.AthighpHvalues,theinversetransformationtakesplace.TheroleofpHdeterminingthepolymerchainsconformationandchargebehaviorofmixedpolyelectrolytebrusheswasanalyzed.Itisfoundthatthereexistsamechanismforreducingstrongelectrostaticrepulsions:stretchingofthechains.TheH+andOH-unitsplayamoreimportantroleascounterionsofthechargedpolymersdo.ThecollapseofthepolyelectrolytechainsfordifferentpHvaluescouldbeattributedtothescreeningoftheelectrostaticinteractionsandthecounterion-mediatedattractiveinteractionalongthechains.
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简介:Helixunwindinginferroelectricliquidcrystalsinducedbyanelectricfieldistheoreticallystudiedonthebasisofthecontinuumtheory.Byapplyingaweakelectricfieldtiltedtothesmecticlayers,thecontributionofthedielectricinteractionenergydensitytothetotalfreeenergydensityisincreased.Approximationmethodsareusedtocalculatethefreeenergyfordifferenttiltanglesbetweentheelectricfieldandthesmecticlayers.Theobtainedresultssuggestselectingtheoptimalnumberofpitchesinthefilmthatmatchestotheminimumofthefreeenergy.
简介:Theproblemoficeinducedvibrationiscommontooceanengineeringofcoldregioncountries.Tostudytheiceinducedvibrationofacompliantconicalstructure,aseriesofmodeltestshavebeenperformedandsomebreakthroughprogressesmade.Theicesheetbeforethecompliantconicalstructureisfoundtofailbytwo-timebreakinginthetests.Theprocessoftwo-timebreakingbehavesintwomodes,andthegeneralcontroloftheiceandstructuralconditionsdeterminethemodeinwhichtheiceforcewouldbehave.Twodynamiciceforcefunctionsareestablishedrespectivelyforthetwomodesoftwo-timebreakingprocessinthispaper.Thenumericalsimulationresultsareingoodagreementwiththemeasuredresults,indicatingthatthedynamiciceforcefunctionsgiveninthispapercanfullyreflecttherealsituationofthedynamiciceforceonacompliantconicalstructure.
简介:The45°scatteringofafemtosecond(60fs)intenselaserpulsewitha20nmFWHM(thefullwidthathalfmaximum)spectrumcenteredat790nmhasbeenstudiedexperimentallywhilefocusedinargonclustersatintensity~1016W/cra2.Scatteringspectraunderdifferentbackingpressuresandlaser-plasmainteractionlengthswereobtained,whichshowedspectralblueshifting,beamrefractionandcomplexmodulation.Theseionization-inducedeffectsrevealthemodulationoflaserpulsespropagatinginplasmasandtheexistingobstacleinlaserclusterinteractionathighlaserintensityandhighelectrondensity.
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简介:TheeffectofreflectionontheperformanceofAM-VSBCATVlightwavesystemsisanalyzed.Usually,therearethreekindsofreflectionexistingintheAM-VSBCATVlightwavesystems:multipathinterference(MPI),doubleRayleighbackscattering(DRB)andexternalopticalfeedbackTheMPIandexternalopticalfeedbackcanbeneglectedowingtousingtheFC/APCconnectorsandisolatedDFBalsersinthesystemlink.ItisshowntheoreticallyandexperimentallythattheDRBisthelimitationofthenoiseinducedbyreflection.