简介:Thepaperdealswiththeinfluenceofanodematerialontheefficiencyofdegradationfororganicpollutantsinwatersystem.Theelectrochemicalperformanceoffluorineiondopedleaddioxide(F--PbO2)electrodeforthedegradationofanilinewascomparedwiththatofundopedleaddioxide(PbO2)electrodebyultraviolet-visible(UV-Vis)spectroscopy,linearvoltammetryandotheranalyticalmethods,suchasthemeasurementbychemicaloxygendemandanalyzer,highperformanceliquidchromatographyandscanningelectronmicrography.ItwasshownthatbothPbO2electrodeandF--PbO2electrodecouldmakeanilinebemineralizedcompletelyandhavethesamedegradationcourse,butF--PbO2electrodehasmuchhigherelectrocatalyticactivitythanundopedPbO2electrodefortheelectrochemicaldegradationofaniline.TheexperimentalresultsconfirmthatF--PbO2electrodehasmuchhigherpotentialforoxygenevolutionthanundopedPbO2electrode.
简介:摘要目的探究E2F2基因在子宫内膜癌中的表达及与生物学行为的相关性。方法选择2015年3月至2018年4月本院妇科获取的30例正常子宫内膜标本、25例子宫内膜增生标本及73例子宫内膜癌组织纳入研究。采用RT-PCR及链霉菌抗生物素蛋白-过氧化酶连接(SP)法测定3种组织E2F2 mRNA表达情况,并分析子宫内膜癌组织E2F2蛋白表达与临床病理参数之间的关系。结果子宫内膜癌组织E2F2 mRNA表达量高于子宫内膜增生组织及正常子宫内膜组织,差异有统计学意义(P<0.05);正常子宫内膜、子宫内膜增生及子宫内膜癌组织E2F2蛋白阳性表达率分别为10.00%、16.00%及52.05%,组间比较差异有统计学意义(P<0.05);国际妇产科联盟(FIGO)分期为Ⅲ~Ⅳ期、中低分化、有淋巴结转移及肌层浸润≥1/2的子宫内膜癌患者E2F2蛋白阳性表达程度显著高于FIGO分期为Ⅰ~Ⅱ期、高分化、无淋巴结转移及肌层浸润<1/2的患者(P<0.05)。结论子宫内膜癌组织E2F2表达上调,其表达程度与患者FIGO分期、分化程度、淋巴结转移及肌层浸润相关。
简介:TheproblemsofcharacteristicpolynomialassignmentinFomasini-Marchesini(F-M)modelⅡof2-Dsystemsareinvestigated.Thecorrespondingclosed-loopsystemsdescribedbyF-MmodelIIareobtainedviathestatefeedback.Usingthealgebraicgeometrymethod,thecharacteristicpolynomialassignmentinthedosed-loopsystemsisdiscussed.Intermsofthetheoryofalgebraicgeometry,theproblemofcharacteristicpolynomialassignmentistransferredtotheonewhetherarationalmappingisonto.SufficientconditionsforalmostarbitraryassignmentcoefficientsofcharacteristicpolynomialinF-MmodelⅡof2-Dsystemsviastatefeedbackarederived,andtheyareavailableformulti-inputcases.Italsohasbeenshownthatthismethodcanbeappliedtoassignthecharacteristicpolynomialwithoutputfeedback.Thesufficientconditionsforalmostarbitraryassignmentcoefficientsofcharacteristicpolynomialofmulti-input2-DsystemsdescribedbyF-MmodelⅡwithoutputfeedbackareestablished.
简介:目的探索不同f2/f1比值对DPOAEs幅值的影响,寻找最佳的测试参数,以得到最大的DPOAEs测值.方法对12例(24耳)正常青年人进行不同f2/f1比值条件下的DPOAEs幅值测试.结果当f1/f1=1.220时,DPOAEs幅值最大(P<0.05或P<0.01).当f2/f1=1.232时,除了f2=2002Hz处以外,其DPOAEs幅值与f2/f1=1.220时无显著性差异(P>0.05).其他f2/f1值的DPOAEs幅值均较低,多数测值与f2/f1=1.220时相比均有显著性差异(P<0.05或P<0.01).结论f2/f1=1.220~1.232时,DPOAEs测值最大,此范围为最佳测试参数值.
简介:Quasiclassicaltrajectorycalculation(QCT)isusedfrequentlyforstudyingcollisionalenergytransferbetweenhighlyvibrationallyexcitedmoleculesandbathgases.Inthispaper,theQCToftheenergytransferbetweenhighlyvibrationallyexcitedC6F6andN2,O2andgroundstateC6F6wereperformed.TheresultsindicatethathighlyvibrationallyexcitedC6F6transferredvibrationalenergytovibrationaldistributionofN2,O2andgroundstateC6F6,sotheyareV-Venergytransfer.EspeciallyitismainlyV-VresonanceenergytransferbetweenexcitedC6F6andgroundstateC6F6,excitedC6F6transfersmorevibrationalenergytogroundstateC6F6thantoN2andO2.ThevaluesofQCT,-〈△Evib〉ofexcitedC6F6aresmallerthanthoseofexperiments.
简介:摘要:本文针对祥云烟区C4F等级质量合格率偏低的问题,通过对部分C4F抽检等级合格率数据统计分析,发现影响C4F等级合格率的主要原因是混入X2F造成的,通过C4F和X2F混级原因分析,提出应对措施并加以实践,最终用数据验证解决措施的可行性和实效性。
简介:AbstractBackground:Pancreatic stellate cells (PSCs) activation plays a critical role in the development of chronic pancreatitis. Previous studies confirmed that thromboxane A2 receptor (TxA2r) was overexpressed in activated PSCs in rats. The purpose of this study was to investigate the role of TxA2r in the activation of PSCs induced by 8-epi-prostaglandin F2α (8-epi-PGF2α).Methods:TxA2r expression in both quiescent and activated PSCs was detected by immunocytochemistry and immunoblot assay. Isolated PSCs were treated with 8-epi-PGF2α (10-6, 10-7, 10-8 mol/L) for 48 h, and SQ29548 (10-4, 10-6, and 10-7 mol/L), a TxA2r-specific antagonist, for 48 h, respectively, to identify the drug concentration with the best biological effect and the least cytotoxicity. Then isolated PSCs were treated with SQ29548 (10-4 mol/L) for 2 h, followed by 10-7 mol/L 8-epi-PGF2α for 48 h. Real-time polymerase chain reaction was performed to detect the messenger RNA (mRNA) levels of α-smooth muscle actin (α-SMA) and collagen I. Comparisons between the groups were performed using Student’s t test.Results:TxA2r was up-regulated in activated PSCs in vitro compared with quiescent PSCs (all P < 0.001). Compared with the control group, different concentrations of 8-epi-PGF2a significantly increased mRNA levels of α-SMA (10-6 mol/L: 2.23 ± 0.18 vs. 1.00 ± 0.07, t= 10.70, P < 0.001; 10-7 mol/L: 2.91 ± 0.29 vs. 1.01 ± 0.08, t= 10.83, P <0.001; 10-8 mol/L, 1.67 ± 0.07 vs. 1.00 ± 0.08, t= 11.40, P < 0.001) and collagen I (10-6 mol/L: 2.68 ± 0.09 vs. 1.00 ± 0.07, t = 24.94, P < 0.001; 10-7 mol/L: 2.12 ± 0.29 vs. 1.01 ± 0.12, t = 6.08, P < 0.001; 10-8 mol/L: 1.46 ± 0.15 vs. 1.00 ± 0.05, t = 4.93, P = 0.008). However, different concentrations of SQ29548 all significantly reduced the expression of collagen I (10-4 mol/L: 0.55 ± 0.07 vs. 1.00 ± 0.07, t = 10.47, P < 0.001; 10-6 mol/L: 0.56 ± 0.10 vs. 1.00 ± 0.07, t = 6.185, P < 0.001; 10-7 mol/L: 0.27 ± 0.04 vs. 1.00 ± 0.07, t= 15.41, P < 0.001) and α-SMA (10-4 mol/L: 0.06 ± 0.01 vs. 1.00 ± 0.11, t= 15.17, P < 0.001; 10-6 mol/L: 0.28 ± 0.03 vs. 1.00 ± 0.11, t= 11.29, P < 0.001; 10-7 mol/L: 0.14 ± 0.04 vs. 1.00 ± 0.11, t= 12.86, P < 0.001). After being treated with SQ29548 (10-4 mol/L) and then 8-epi-PGF2α (10-7 mol/L), the mRNA levels of a-SMA (0.20 ± 0.08 vs. 1.00 ± 0.00, t= 17.46, P < 0.001) and collagen I (0.69 ± 0.13 vs. 1.00 ± 0.00, t = 4.20, P = 0.014) in PSCs were significantly lower than those of the control group.Conclusions:The results show that 8-epi-PGF2α promoted PSCs activation, while SQ29548 inhibited PSCs activation induced by 8-epi-PGF2α. The result indicated that TxA2r plays an important role during PSC activation and collagen synthesis induced by 8-epi-PGF2αin vitro. This receptor may provide a potential target for more effective antioxidant therapy for pancreatic fibrosis.