简介:Aseriesof2’-purineandpyrimidinederivativesof1’,4’-anhy-dro-2’-deoxy-D-arabitol(1)and1’,4’-anhydro-2’-deoxy-D-altritol(2)weresynthesizedregio-andstereo-selectivelyfromD-sorbitolthroughsomeconversioninhighyields.
简介:为探索以D-甘露糖与氨基酸的美拉德反应制备Amadori化合物的可行性问题,以D-甘露糖和L-色氨酸为原料合成了1-L-色氨酸-1-脱氧-D-果糖,利用IR、NMR和HR-MS对产物进行了结构表征,采用单因素试验和正交试验优化了合成工艺,利用在线裂解气相色谱/质谱联用(Py-GC/MS)法研究了产物的热裂解行为。结果表明:(1)最佳合成条件为:当L-色氨酸投料量为30mmol时,反应温度65℃、反应时间6.0h、物料比1:1(D-甘露糖与L-色氨酸的物质的量比)、催化剂用量0.5mmol及溶剂用量80mL,此条件下产率达到45.2%;(2)无论有氧或无氧条件下裂解,产物种类均随温度升高而增加,有氧条件裂解产物种类多于无氧条件;在600℃有氧条件下,1-L-色氨酸-1-脱氧-D-果糖裂解生成具有花香、烘烤香、坚果香、焦糖香等香韵的产物;(3)以D-甘露糖和L-色氨酸为原料合成1-L-色氨酸-1-脱氧-D-果糖的技术方法可行,产品收率较高。
简介:教学目标:基础性目标:I.Knowledgeobjectives:Tolearntousethepresentprogressivetense.II.Abilityobjectives:Tolearntotalkaboutwhatpeoplearedoing.III.Moralobjective:Tolearntogetalongwellwithourfamilymembers,neighborsandfriends.Companyisthelongestconfessionoflove.发展性目标:1.Tohelpthestudentsdevelopthelisteningandspeakingskills.2.Toleadthestudentstoenhancetheresponsibilitiesofhome.
简介:恶性肿瘤是一类细胞周期疾病,几乎所有癌基因、抑癌基因的生物学效应,最终都会集到细胞周期机制上来。细胞周期蛋白D1(CyclinD1)作用于细胞周期的G1→S期调控点,为G1期的限速步骤。研究CyclinD1与头颈部恶性肿瘤发生发展的关系,对了解头颈部恶性肿瘤的发病机制以及基因疗法的开展提供依据。本文对CyclinD1在头颈部恶性肿瘤发生发展中的作用做一综述。
简介:Basedonconsolidationequationsproposedforunsaturatedsoil,ananalyticalsolutionfor1Dconsolidationofanunsaturatedsingle-layersoilwithnonhomogeneousmixedboundaryconditionisdeveloped.Themixedboundaryconditioncanbeusedforspecialapplications,suchastestsoccurinlaboratory.Theanalyticalsolutionisobtainedbyassumingallmaterialparametersremainconstantduringconsolidation.Inthederivationoftheanalyticalsolution,thenonhomogeneousboundaryconditionisfirsttransformedintoahomogeneousboundarycondition.Then,theeigenfunctionandeigenvaluearederivedaccordingtotheconsolidationequationsandthenewboundarycondition.Finally,usingthemethodofundeterminedcoefficientsandtheorthogonalrelationoftheeigenfunction,theanalyticalsolutionforthenewboundaryconditionisobtained.Thepresentmethodisapplicabletovarioustypesofboundaryconditions.Severalnumericalexamplesareprovidedtoinvestigatetheconsolidationbehaviorofanunsaturatedsingle-layersoilwithmixedboundarycondition.
简介:Inthispaper,ahigh-orderfinite-volumeschemeispresentedfortheone-dimensionalscalarandinviscidEulerconservationlaws.TheSimpson’squadratureruleisusedtoachievehigh-orderaccuracyintime.TogetthepointvalueoftheSimpson’squadrature,thecharacteristictheoryisusedtoobtainthepositionsofthegridpointsateachsub-timestagealongthecharacteristiccurves,andthethird-orderandfifth-ordercentralweightedessentiallynon-oscillatory(CWENO)reconstructionisadoptedtoestimatethecellpointvalues.Severalstandardone-dimensionalexamplesareusedtoverifythehigh-orderaccuracy,convergenceandcapabilityofcapturingshock.
简介:目的探讨细胞周期素(cyelin)D1/D2/D3在大鼠脑胶质瘤动物模型肿瘤组织中的表达。方法将体外培养大鼠C6胶质瘤细胞(细胞数为3×10^5个),借助动物立体定向仪接种于Wistar大鼠左侧尾状核区,解剖标本,行组织病理学检查,胶质纤维酸性蛋白(GFAP)免疫组化定性监测。随后检测肿瘤组织中cyclinD1/D2/D3蛋白表达。结果cyclinD1/D2/D3均呈阳性表达。cyclinD1/D3主要在细胞核表达;cyclinD2则主要在胞浆表达,部分细胞核呈阳性,不同存活期荷瘤鼠其瘤组织中cyclinD1/D2/D3表达量不同。结论cyelinD1/D2/D3的过分表达,对大鼠脑胶质瘤细胞增殖的失控起着一定的调节作用。荷瘤鼠生存期与cyclinD族的表达量呈负相关关系。
简介:Backoffmechanismisakeycomponentofcontention-basedmediumaccesscontrol(MAC)layerprotocol.IthasbeenshownthatthebackoffmechanismofIEEE802.11standardmaybeveryinefficientespeciallywhenthenetworkiscongested.Numbersofmethodshavebeenproposedtotunethecontentionwindow(CW)withtheaimtoachievetheoptimalthroughputinIEEE802.11WLANs.However,themechanismsdonotspecificallyaddresspropersettingsforthevariablepacketlengthinfluenceandCWdivergingproblem.Thispaperproposesanovelfour-wayhandshakingfull-feedbackbackoffalgorithmnamedadoptivecontentionwindowbackoff(ACWB)toovercomethesedrawbacks.Theperformanceoftheproposedalgorithmisinvestigatedthroughanalysisandsimulation.SimulationresultsdemonstratethattheACWBalgorithmprovidesaremarkableperformanceimprovementintermsofshort-termfairness,packetdelayanddelayjitter,whilemaintaininganoptimalthroughputclosetothetheoreticalthroughputlimitoftheIEEE802.11distributedcoordinationfunction(DCF)accessscheme.